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Technology Development

Technology Development

Personalized Diagnostics VirScan Peptide and Peptidomimetic Library Synthesis Genomics, Proteomics and Bioinformatics Creating custom libraries: CRISPR Expression libraries Transcription factors (human) Epigenetic factors (human) All coding genes (human) shRNA libraries NAPPA protein arrays

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Breast Cancer Early Detection and Progression

Breast Cancer Early Detection and Progression

Interfacing new imaging technologies with machine learning to identify characteristics of high risk breast tissue Defining the molecular switches of early tumor progression Defining abnormal molecular events in normal breast tissues that precede the onset of cancer

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Ben Dake

Ben Dake

Metastasis is the ultimate and fatal stage of breast cancer progression. Ben has developed a metastasis model to track seeding and outgrowth of human tumor cells systemically in immunocompromised mice by delivering cells intracardially. His work has examined potential roles for chromatin modifiers in metastasis, implicated endocrine messengers in colonization of the brain and adrenal […]

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Jessica Elman

Jessica Elman

Our lab has shown that lineage-committed mammary epithelial cells can have bipotent character by stimulating luminal cells to adopt a basal phenotype. My project focuses on elucidating whether the reverse of this phenomenon can be induced, namely I aim to study whether basal cells can acquire a luminal phenotype.

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Kayla Gross

Kayla Gross

Our lab focuses on investigating the molecular mechanisms that drive normal breast development and how these processes become disrupted in cancerous tissue. More specifically, we are interested in the role of stem and progenitor cells in both normal and carcinogenic development, especially the molecular drivers of breast epithelial differentiation. Previous work recently established the transcription […]

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Wenhui Zhou

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Jerrica Breindel, Ph.D.

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Andrew DeCastro, Ph.D.

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Thomas K. Ni, Ph.D.

Thomas K. Ni, Ph.D.

American Cancer Society Postdoctoral Fellow

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Ania Wronski, Ph.D.

Ania Wronski, Ph.D.

Over the past several years, genome sequencing has led to unparalleled, multifaceted analysis of the genetic and molecular landscape of human cancer, in particular breast cancer. Ideally, this information could enable medical professionals to make better decisions regarding treatment regimes. Perhaps the most exciting potential of this new personalised medicine era is the ability to […]

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