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Convergence Lab Member Stephen J. Elledge awarded 2017 Breakthrough Prize in Life Sciences

Convergence Lab Member Stephen J. Elledge awarded 2017 Breakthrough Prize in Life Sciences

The Breakthrough Prize and founders Sergey Brin and Anne Wojcicki, Yuri and Julia Milner, and Mark Zuckerberg and Priscilla Chan, tonight announced the recipients of the 2017 Breakthrough Prizes, marking the organization’s fifth anniversary recognizing top achievements in Life Sciences, Fundamental Physics and Mathematics. A combined total of $25 million was awarded at the gala ceremony in Silicon Valley, hosted by Morgan Freeman. Each of the Breakthrough Prizes is worth $3 million, the largest individual monetary prize in science.

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Convergence Lab Director Charlotte Kuperwasser’s new study reveals underlying molecular mechanisms that drive malignancy and aggressiveness in basal-like breast cancer

Convergence Lab Director Charlotte Kuperwasser’s new study reveals underlying molecular mechanisms that drive malignancy and aggressiveness in basal-like breast cancer

Silencing SIRT2, a member of the sirtuin family of enzymes, reduces the invasiveness of basal-like breast cancer cells in culture and inhibits tumor growth in mice, according to new research led by scientists from Tufts University School of Medicine and the Sackler School of Graduate Biomedical Sciences at Tufts in Boston. The absence of SIRT2 appears to accelerate the degradation of Slug, a transcription factor that has previously been implicated in tumor progression and metastasis.

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Convergence lab member Andrew Beck part of research team developing artificial intelligence (AI) methods aimed at training computers to interpret pathology images

Convergence lab member Andrew Beck part of research team developing artificial intelligence (AI) methods aimed at training computers to interpret pathology images

Pathologists have been largely diagnosing disease the same way for the past 100 years, by manually reviewing images under a microscope. But new work suggests that computers can help doctors improve accuracy and significantly change the way cancer and other diseases are diagnosed.

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Convergence lab member Piyush Gupta has grown tissue that can produce breast milk in a lab

Convergence lab member Piyush Gupta has grown tissue that can produce breast milk in a lab

Scientists have created a hydrogel scaffold that mimics the environment of human breast tissue. By seeding it with patient-derived cells they can create models of individual tumors to study in the lab. Here’s what researcher Piyush Gupta of MIT’s Whitehead Institute had to say about the research, published in the journal Breast Cancer Research.

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Convergence lab member Andrew Beck uses crowdsourcing to develop computer cancer diagnostic

Convergence lab member Andrew Beck uses crowdsourcing to develop computer cancer diagnostic

Convergence lab member Andrew Beck  is looking to change how doctors diagnose cancer, and the key might lie in crowdsourcing. Researchers at Beth Israel Deaconess are using crowdsourcing, through the website CrowdFlower, to develop labeled images of tumor tissues. Scientists hope to use this data to better train a computer algorithm to read tissue samples […]

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Crossing Disciplines to Fight Disease

Crossing Disciplines to Fight Disease

An innovative Tufts laboratory that brings biologists together with chemists and mathematicians is poised to yield new insights into breast cancer.

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Convergence lab member Steve Elledge wins the Lasker Award

Convergence lab member Steve Elledge wins the Lasker Award

Harvard geneticist Stephen Elledge started his scientific career trying to figure out how to tinker with the DNA of human cells. Instead, he ended up eavesdropping on the process cells use to fix genetic mistakes. This accidental work led to profound insights into DNA repair relevant to human birth defects, cancer, and aging. On Tuesday, […]

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Sackler Lab member Steve Elledge develops new method to reveal entire history of viral infections in a single drop of blood

Sackler Lab member Steve Elledge develops new method to reveal entire history of viral infections in a single drop of blood

Researchers have developed a cheap and rapid test that reveals a person’s full history of viral infections from a single drop of blood. The test allows doctors to read out a list of the viruses that have infected, or continue to infect, patients even when they have not caused any obvious symptoms. The technology means […]

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Convergence Lab Member Josh Kritzer sheds insights into drugging the undruggable

Convergence Lab Member Josh Kritzer sheds insights into drugging the undruggable

The application of macrocycles to previously undruggable targets has aroused a great deal of interest in this structural class. Recent studies advance our understanding of the way macrocycles bind protein targets and provide new strategies and tools to generate peptide-based macrocycles.

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Convergence Lab Member Piyush Gupta identifies gene required for differentiation of breast stem cells

Convergence Lab Member Piyush Gupta identifies gene required for differentiation of breast stem cells

CAMBRIDGE, Mass. – A novel analytical method has enabled Whitehead Institute scientists to identify a regulatory gene required for breast stem cells to differentiate. Inhibition of this gene, known as RUNX1, prevents cells from exiting the stem cell state. “We’re very excited about this finding, as it suggests a new solution to the problem of […]

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